# STOCKHOLM 1.0
#=GF ID   fn3
#=GF AC   PF00041.20
#=GF DE   Fibronectin type III domain
#=GF AU   Sonnhammer ELL
#=GF SE   Swissprot_feature_table
#=GF GA   24.50 24.50;
#=GF TC   24.50 24.50;
#=GF NC   24.40 24.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Fibronectin_type_III_domain
#=GF RN   [1]
#=GF RM   2169613
#=GF RT   Structural design and molecular evolution of a cytokine receptor
#=GF RT   superfamily. 
#=GF RA   Bazan JF; 
#=GF RL   PNAS USA 1990;87:6934-6938.
#=GF RN   [2]
#=GF RM   7528812
#=GF RT   Tracing the spread of fibronectin type III domains in bacterial
#=GF RT   glycohydrolases. 
#=GF RA   Little E, Bork P, Doolittle R; 
#=GF RL   J Mol Evol 1994;39:631-643.
#=GF RC   Definition of fibronectin domains
#=GF RN   [3]
#=GF RM   2992939
#=GF RT   Primary structure of human fibronectin: differential splicing
#=GF RT   may generate at least 10 polypeptides from a single gene. 
#=GF RA   Kornblihtt AR, Umezawa K, Vibe-Pedersen K, Baralle FE; 
#=GF RL   EMBO J 1985;4:1755-1759.
#=GF DR   INTERPRO; IPR003961;
#=GF DR   PROSITE; PDOC00214;
#=GF DR   PRINTS; PR00014;
#=GF DR   SCOP; 1ttf; sf;
#=GF DR   SMART; FN3;
#=GF DR   HOMSTRAD; fn3;
#=GF SQ   98
#=GS LAR_DROME/418-503      AC P16621.2
#=GS TENA_CHICK/1495-1571   AC P10039.2
#=GS KALM_CHICK/544-641     AC P33005.2
#=GS LAR_DROME/710-800      AC P16621.2
#=GS PTP99_DROME/172-259    AC P35832.2
#=GS IL7RA_HUMAN/130-218    AC P16871.2
#=GS IL7RA_HUMAN/130-218    DR PDB; 3UP1 A; 110-198;
#=GS IL7RA_HUMAN/130-218    DR PDB; 3DI2 D; 110-198;
#=GS IL7RA_HUMAN/130-218    DR PDB; 3DI2 B; 110-198;
#=GS IL7RA_HUMAN/130-218    DR PDB; 3UP1 B; 110-198;
#=GS IL7RA_HUMAN/130-218    DR PDB; 3DI3 B; 110-198;
#=GS TIE2_HUMAN/445-529     AC Q02763.2
#=GS TIE2_HUMAN/445-529     DR PDB; 4K0V A; 445-530;
#=GS TIE1_HUMAN/447-533     AC P35590.1
#=GS PTPRK_MOUSE/291-376    AC P35822.1
#=GS PTP10_DROME/218-301    AC P35992.4
#=GS PTP10_DROME/124-205    AC P35992.4
#=GS FINC_BOVIN/1635-1713   AC P07589.4
#=GS FINC_BOVIN/1176-1257   AC P07589.4
#=GS FINC_BOVIN/1907-1984   AC P07589.4
#=GS FINC_RAT/1267-1346     AC P04937.2
#=GS FINC_BOVIN/909-987     AC P07589.4
#=GS FINC_BOVIN/1360-1439   AC P07589.4
#=GS FINC_BOVIN/1815-1893   AC P07589.4
#=GS TENA_CHICK/683-767     AC P10039.2
#=GS TENA_CHICK/775-853     AC P10039.2
#=GS FINC_BOVIN/1451-1529   AC P07589.4
#=GS TENA_CHICK/1318-1395   AC P10039.2
#=GS TENA_CHICK/1318-1395   DR PDB; 1QR4 B; 89-168;
#=GS TENA_CHICK/1318-1395   DR PDB; 1QR4 A; 89-168;
#=GS TENA_CHICK/594-671     AC P10039.2
#=GS TENA_CHICK/957-1033    AC P10039.2
#=GS TENA_CHICK/957-1033    DR PDB; 1QR4 B; 89-168;
#=GS TENA_CHICK/957-1033    DR PDB; 1QR4 A; 89-168;
#=GS TENA_CHICK/865-945     AC P10039.2
#=GS FINC_BOVIN/1541-1622   AC P07589.4
#=GS FINC_BOVIN/1996-2074   AC P07589.4
#=GS TENA_CHICK/1407-1483   AC P10039.2
#=GS PTP69_DROME/333-425    AC P16620.2
#=GS FINC_BOVIN/813-890     AC P07589.4
#=GS FINC_BOVIN/722-800     AC P07589.4
#=GS PTPRB_HUMAN/1356-1434  AC P23467.3
#=GS PTP10_DROME/406-485    AC P35992.4
#=GS PTPRB_HUMAN/468-543    AC P23467.3
#=GS PTP10_DROME/313-394    AC P35992.4
#=GS PTPRB_HUMAN/113-192    AC P23467.3
#=GS PTPRB_HUMAN/644-725    AC P23467.3
#=GS PTPRB_HUMAN/732-808    AC P23467.3
#=GS PTPRB_HUMAN/908-984    AC P23467.3
#=GS PTPRB_HUMAN/996-1074   AC P23467.3
#=GS PTPRB_HUMAN/555-632    AC P23467.3
#=GS PTPRB_HUMAN/1086-1162  AC P23467.3
#=GS PTPRB_HUMAN/1174-1250  AC P23467.3
#=GS PTPRB_HUMAN/1262-1344  AC P23467.3
#=GS PTP10_DROME/865-939    AC P35992.4
#=GS PTP10_DROME/584-661    AC P35992.4
#=GS NGCA_CHICK/702-794     AC Q03696.2
#=GS CNTN2_CHICK/604-692    AC P28685.1
#=GS MYPC2_CHICK/632-717    AC P16419.3
#=GS MPSF_CHICK/700-785     AC Q02173.1
#=GS MPSF_CHICK/802-887     AC Q02173.1
#=GS MPSF_CHICK/372-457     AC Q02173.1
#=GS MPSF_CHICK/500-585     AC Q02173.1
#=GS MYPC2_CHICK/925-1006   AC P16419.3
#=GS F4H3U7_CELFA/652-733   AC F4H3U7.1
#=GS MYLK_CHICK/1319-1403   AC P11799.2
#=GS MPSF_CHICK/601-684     AC Q02173.1
#=GS NRCAM_CHICK/624-709    AC P35331.1
#=GS LAR_DROME/323-404      AC P16621.2
#=GS NCAM1_BOVIN/611-691    AC P31836.1
#=GS NCAM1_BOVIN/510-597    AC P31836.1
#=GS FINC_BOVIN/610-692     AC P07589.4
#=GS PTPRB_HUMAN/24-103     AC P23467.3
#=GS TIE2_HUMAN/640-724     AC Q02763.2
#=GS PTP69_DROME/237-321    AC P16620.2
#=GS TENA_CHICK/1228-1306   AC P10039.2
#=GS TENA_CHICK/1046-1124   AC P10039.2
#=GS TENA_HUMAN/1257-1335   AC P24821.3
#=GS TENA_CHICK/1137-1215   AC P10039.2
#=GS TENA_HUMAN/1530-1608   AC P24821.3
#=GS EPHB2_CHICK/327-422    AC P28693.3
#=GS EPHA3_CHICK/326-421    AC P29318.1
#=GS EPHA1_HUMAN/334-431    AC P21709.4
#=GS EPHA2_HUMAN/330-419    AC P29317.2
#=GS EPHA2_HUMAN/330-419    DR PDB; 3FL7 A; 437-519;
#=GS EPHA2_HUMAN/330-419    DR PDB; 3MX0 C; 330-424;
#=GS EPHA2_HUMAN/330-419    DR PDB; 2X11 A; 438-519;
#=GS EPHA2_HUMAN/330-419    DR PDB; 3MX0 A; 330-424;
#=GS EPHA2_HUMAN/330-419    DR PDB; 2X10 A; 437-519;
#=GS 7LESS_DROVI/1918-1997  AC P20806.1
#=GS TIE2_HUMAN/544-626     AC Q02763.2
#=GS KALM_CHICK/178-269     AC P33005.2
#=GS LAR_DROME/516-598      AC P16621.2
#=GS PTPRZ_HUMAN/313-401    AC P23471.4
#=GS EPHA2_HUMAN/437-519    AC P29317.2
#=GS EPHA2_HUMAN/437-519    DR PDB; 3FL7 A; 437-519;
#=GS EPHA2_HUMAN/437-519    DR PDB; 2X11 A; 438-519;
#=GS EPHA2_HUMAN/437-519    DR PDB; 2X10 A; 437-519;
#=GS TIE1_HUMAN/645-729     AC P35590.1
#=GS ITB4_HUMAN/1529-1612   AC P16144.5
#=GS ITB4_HUMAN/1529-1612   DR PDB; 4WTW A; 1459-1542;
#=GS ITB4_HUMAN/1529-1612   DR PDB; 4WTW B; 1459-1542;
#=GS ITB4_HUMAN/1529-1612   DR PDB; 2YRZ A; 19-102;
#=GS ITB4_HUMAN/1221-1310   AC P16144.5
#=GS ITB4_HUMAN/1221-1310   DR PDB; 3F7P D; 1221-1310;
#=GS ITB4_HUMAN/1221-1310   DR PDB; 3F7Q B; 1221-1310;
#=GS ITB4_HUMAN/1221-1310   DR PDB; 3F7P E; 1221-1310;
#=GS ITB4_HUMAN/1221-1310   DR PDB; 4Q58 D; 1221-1310;
#=GS ITB4_HUMAN/1221-1310   DR PDB; 1QG3 B; 1221-1310;
#=GS ITB4_HUMAN/1221-1310   DR PDB; 3F7P C; 1221-1310;
#=GS ITB4_HUMAN/1221-1310   DR PDB; 4Q58 C; 1221-1310;
#=GS ITB4_HUMAN/1221-1310   DR PDB; 3F7Q A; 1221-1310;
#=GS ITB4_HUMAN/1221-1310   DR PDB; 1QG3 A; 1221-1310;
#=GS ITB4_HUMAN/1221-1310   DR PDB; 3F7R A; 1221-1310;
#=GS ITB4_HUMAN/1642-1728   AC P16144.5
#=GS ITB4_HUMAN/1642-1728   DR PDB; 4WTX A; 1572-1658;
#=GS PTP10_DROME/959-1044   AC P35992.4
#=GS EPHB2_CHICK/438-521    AC P28693.3
#=GS EPHA4_MOUSE/442-525    AC Q03137.2
#=GS LAR_DROME/911-995      AC P16621.2
#=GS NRCAM_CHICK/929-1014   AC P35331.1
#=GS 7LESS_DROME/1800-1891  AC P13368.2
#=GS E1JJF8_DROME/918-1007  AC E1JJF8.1
#=GS ITB4_HUMAN/1128-1208   AC P16144.5
#=GS ITB4_HUMAN/1128-1208   DR PDB; 3F7P D; 1221-1310;
#=GS ITB4_HUMAN/1128-1208   DR PDB; 3F7Q B; 1221-1310;
#=GS ITB4_HUMAN/1128-1208   DR PDB; 3F7P E; 1221-1310;
#=GS ITB4_HUMAN/1128-1208   DR PDB; 4Q58 D; 1221-1310;
#=GS ITB4_HUMAN/1128-1208   DR PDB; 1QG3 B; 1221-1310;
#=GS ITB4_HUMAN/1128-1208   DR PDB; 3F7P C; 1221-1310;
#=GS ITB4_HUMAN/1128-1208   DR PDB; 4Q58 C; 1221-1310;
#=GS ITB4_HUMAN/1128-1208   DR PDB; 3F7Q A; 1221-1310;
#=GS ITB4_HUMAN/1128-1208   DR PDB; 1QG3 A; 1221-1310;
#=GS ITB4_HUMAN/1128-1208   DR PDB; 3F7R A; 1221-1310;
#=GS UFO_HUMAN/335-418      AC P30530.3
#=GS E1JJF8_DROME/817-905   AC E1JJF8.1
#=GS CNTN2_CHICK/809-896    AC P28685.1
#=GS CNTN1_CHICK/801-884    AC P14781.1
#=GS CNTN1_CHICK/801-884    DR PDB; 5E53 A; 801-884;
#=GS CNTN1_CHICK/801-884    DR PDB; 5E53 C; 801-884;
#=GS CNTN1_CHICK/801-884    DR PDB; 5E53 D; 801-884;
#=GS CNTN1_CHICK/801-884    DR PDB; 5E53 B; 801-884;
#=GS TIE1_HUMAN/547-632     AC P35590.1
#=GS L1CAM_HUMAN/813-907    AC P32004.2
LAR_DROME/418-503                 SAP.RNVQVRTL...SSSTMVITWEPPE..TPNGQVTGYKV.Y...YTTNSNQP.......EASWNSQM...VDNS....E...LTTVSEL.TPHAIYTVRVQ.AYTSMG..AGPMS
TENA_CHICK/1495-1571              DAP.KDLSATEV...QSETAVITWRPP.....RAPVTDYLLTY...ESI.DGR...........VKEVI...LDPE....TT..SYTLTEL.SPSTQYTVKLQ.ALSRS.....MRS
KALM_CHICK/544-641                AKP.ENLSASFIVQEGNITGHFSWKISK.AVLHQPMTGFQVTW...AEVTTESRQNS.LPNSIISQSQI...LPAD....HY..VLTVPNL.RPSMLYRLEVQ.VLTTGG..EGPAT
LAR_DROME/710-800                 GDP.QDVKATPL...NSTSIHVSWKPPLEKDRNGIIRGYHIHA...QELRDEGKG.....FLNEPFKFD...VVDT....L...EFNVTGL.QPDTKYSIQVA.ALTRKG..DGDRS
PTP99_DROME/172-259               SKP.QNLTILDV...SANSITMSWHPPK..NQNGAIAGYHVFH...IHDNQTGV.......EIVKNSRN...SVET....LI..HFELQNL.RPYTDYRVIVK.AFTTKN..EGEPS
IL7RA_HUMAN/130-218               EAP.FDLSVIYR..EGANDFVVTFNTSHLQKKYVKVLMHDVAY...RQEKDEN..........KWTHVN...LSST....KL..TLLQRKL.QPAAMYEIKVR.SIPDHY.FKGFWS
#=GR IL7RA_HUMAN/130-218    SS    ---.EEEEEEEE..TTTTEEEEEEE-GGGGHSSST-EEEEEEE...EESSSSS..........S-EEEE...ESSS....EE..EEEGGGS.-SSEEEEEEEE.EEE-SS.S-B---
TIE2_HUMAN/445-529                PKPLNAPNVIDT...GHNFAVINISSEP.YFGDGPIKSKKLLY...KPVNHYE..........AWQHIQ...VTNE....I....VTLNYL.EPRTEYELCVQ.LVRRGE..GGEGH
#=GR TIE2_HUMAN/445-529     SS    --BSS--EEEE-...-TT--EEE---SS.BSS-S-----EEEE...E-SS---..........---B--...SSEE....E....--S--S.S--EEEEEE--.-SSSS-..-----
TIE1_HUMAN/447-533                PVPLAAPRLLTK...QSRQLVVSPLVSF..SGDGPISTVRLHY..RPQDSTMD...........WSTIV...VDPS....E...NVTLMNL.RPKTGYSVRVQLSRPGEG.GEGAWG
PTPRK_MOUSE/291-376               PRPIAPPQLLGV...GPTYLLIQLNANS.IIGDGPIILKEVEY..R.MT.SGS...........WTETH...AVNA....P...TYKLWHL.DPDTEYEIRVLLTRPGEG.GTGLPG
PTP10_DROME/218-301               NTP.GKFIVWFR...NETTLLVLWQPP...YPAGIYTHYKVSI...EPPDANDSV......LYVEKEGE...PPGP....A...QAAFKGL.VPGRAYNISVQ.TMSED.....EIS
PTP10_DROME/124-205               DPP.SNLSVQVR...SGKNAIILWSPPT....QGSYTAFKIKV...LGLSEASS........SYNRTFQ...VNDN....TF..QHSVKEL.TPGATYQVQAY.TIYDG.....KES
FINC_BOVIN/1635-1713              DKP.SQMQVTDV...QDNSISVRWLPS.....SSPVTGYRVTT...APKNGPG..........PSKTKT...VGPD....QT..EMTIEGL.QPTVEYVVSVY.AQNQN.....GES
FINC_BOVIN/1176-1257              SPP.TNLHLEAN..PDTGVLTVSWERST....TPDITGYRITT...TPTNGQQ.........GYSLEEV...VHAD....QS..SCTFENL.SPGLEYNVSVY.TVKDD.....KES
FINC_BOVIN/1907-1984              SPP.RRARVTDA...TETTITISWRTK.....TETITGFQVDA...IPANGQT...........PIQRT...IRPD....VR..SYTITGL.QPGTDYKIHLY.TLNDN.....ARS
FINC_RAT/1267-1346                PQL.TDLSFVDI...TDSSIGLRWTPLN....SSTIIGYRITV...VAAGEGI..........PIFEDF...VDSS....VG..YYTVTGL.EPGIDYDISVI.TLING.....GES
FINC_BOVIN/909-987                PPP.RDLQFVEV...TDVKITIMWTPP.....ESPVTGYRVDV...IPVNLPG.........EHGQRLP...VSRN....T...FAEVTGL.SPGVTYHFKVF.AVNQG.....RES
FINC_BOVIN/1360-1439              PPP.TDLRFTNV...GPDTMRVTWAPPS....SIELTNLLVRY...SPVKNEE..........DVAELS...ISPS....DN..AVVLTNL.LPGTEYLVSVS.SVYEQ.....HES
FINC_BOVIN/1815-1893              PAP.TNLKFTQV...TPTSLTAQWTAP.....NVQLTGYRVRV...TPKEKTG..........PMKEIN...LAPD....SS..SVVVSGL.MVATKYEVSVY.ALKDT.....LTS
TENA_CHICK/683-767                PAP.EGLKFKSV...RETSVQVEWDPL.....SISFDGWELVFRNMQKKDDNG...........DITSS...LKRP....ET..SYMQPGL.APGQQYNVSLH.IVKNNT.RGPGLS
TENA_CHICK/775-853                DAP.SQIEAKDV...TDTTALITWSKP.....LAEIEGIELTY...GPKDVPG..........DRTTID...LSED....EN..QYSIGNL.RPHTEYEVTLI.SRRGD.....MES
FINC_BOVIN/1451-1529              DSP.SGIDFSDI...TANSFTVHWIAP.....RATITGYRIRH...HPENMGG..........RPREDR...VPPS....RN..SITLTNL.NPGTEYVVSIV.ALNSK.....EES
TENA_CHICK/1318-1395              GSP.KGISFSDI...TENSATVSWTPP.....RSRVDSYRVSY...VPITGGT...........PNVVT...VDGS....KT..RTKLVKL.VPGVDYNVNII.SVKGF.....EES
#=GR TENA_CHICK/1318-1395   SS    ---.SEEEEES-...-SS-EEEEEE--.....SS--SEEEEEE...EETT---...........-EEEE...EETT....-S..EEEE-S-.-SS-EEEEEEE.EEETT.....EE-
TENA_CHICK/594-671                SPP.TELTVTNV...TDKTVNLEWKHE......NLVNEYLVTY...VPTSSGG..........LDLQFT...VPGN....QT..SATIHEL.EPGVEYFIRVF.AILKN.....KKS
TENA_CHICK/957-1033               DNP.KDLEVSDP...TETTLSLRWRRP.....VAKFDRYRLTY...VSP.SGK...........KNEME...IPVD....ST..SFILRGL.DAGTEYTISLV.AEKGR.....HKS
#=GR TENA_CHICK/957-1033    SS    ---.EEEEEES-...-SSEEEEEEE--.....SS--SEEEEEE...E-T.T--...........EEEEE...E-TT....-S..EEEEES-.-TT-EEEEEEE.EESSS.....-B-
TENA_CHICK/865-945                DAP.RNLKRVSQ...TDNSITLEWKNS.....HANIDNYRIKF...APISGGD...........HTELT...VPKGN.QATT..RATLTGL.RPGTEYGIGVT.AVRQD.....RES
FINC_BOVIN/1541-1622              DVP.RDLEVIAA...TPTSLLISWDAP.....AVTVRYYRITY...GETGGSS..........PVQEFT...VPGS....KS..TATISGL.KPGVDYTITVY.AVTGRG..DSPAS
FINC_BOVIN/1996-2074              DAP.SNLRFLAT...TPNSLLVSWQPP.....RARITGYIIKY...EKPGSPP.........REVVPRP...RPGV....T...EATITGL.EPGTEYTIQVI.ALKNN.....QKS
TENA_CHICK/1407-1483              DSP.SGLVVMNI...TDSEALATWQPA.....IAAVDNYIVSY...SSEDEP............EVTQM...VSGN....TV..EYDLNGL.RPATEYTLRVH.AVKDA.....QKS
PTP69_DROME/333-425               DPI.FIPKVETTG.STASTITIGWNPPP.PDLIDYIQYYELIV...SESGEVPKV......IEEAIYQQ...NSRN....L...PYMFDKL.KTATDYEFRVR.ACSDLTKTCGPWS
FINC_BOVIN/813-890                DAP.PDPTVDQV...DDTSIVVRWSRP.....RAPITGYRIVY...SPSVEGS...........STELN...LPET....AN..SVTLSDL.QPGVQYNITIY.AVEEN.....QES
FINC_BOVIN/722-800                VVA.TSESVTEI...TASSFVVSWVSA.....SDTVSGFRVEY...ELSEEGD..........EPQYLD...LPST....AT..SVNIPDL.LPGRKYTVNVY.EISEE.....GEQ
PTPRB_HUMAN/1356-1434             DKI.QNLHCRPQ...NSTAIACSWIPP.....DSDFDGYSIEC...RKMDTQE..........VEFSRK...LEKE....KS..LLNIMML.VPHKRYLVSIK.VQSAG.....MTS
PTP10_DROME/406-485               LPV.RNLRSIND..DKTNTMIITWEADP....ASTQDEYRIVY...HELETFN...........GDTST...LTTD....RT..RFTLESL.LPGRNYSLSVQ.AVSKK.....MES
PTPRB_HUMAN/468-543               LAV.LQLRVKHA...NETSLSIMWQTP.....VAEWEKYIISL...ADRDLL............LIHKS...LSKD....AK..EFTFTDL.VPGRKYMATVT.SISGD......LK
PTP10_DROME/313-394               LRP.LNVTFDRDF.ITSNSFRVLWEAPK...GISEFDKYQVSV...ATTRRQS...........TVPRS...NEPV....A...FFDFRDIAEPGKTFNVIVK.TVSGK.....VTS
PTPRB_HUMAN/113-192               PAR.FGVSKEKT...TSTSLHVWWTPS.....SGKVTSYEVQL...FDENNQKI.......QGVQIQES...TSWN....E....YTFFNL.TAGSKYNIAIT.AVSGG.....KRS
PTPRB_HUMAN/644-725               SSV.SGVTVNNS..GRNDYLSVSWLLA.....PGDVDNYEVTL...SHDGKV............VQSLV...IAKS....VR..ECSFSSL.TPGRLYTVTIT.TRSGKY.ENHSFS
PTPRB_HUMAN/732-808               DKV.QGVSVSNS..ARSDYLRVSWVHA.....TGDFDHYEVTI...KNKNNF............IQTKS...IPKS....EN..ECVFVQL.VPGRLYSVTVT.TKSGQ......YE
PTPRB_HUMAN/908-984               SAV.KNIHISPN..GATDSLTVNWTPG.....GGDVDSYTVSA...FRH.SQK...........VDSQT...IPKH....VF..EHTFHRL.EAGEQYQIMIA.SVSGS......LK
PTPRB_HUMAN/996-1074              ASV.QGVIADNA..YSSYSLIVSWQKA.....AGVAERYDILL...LTENGIL...........LRNTS...EPAT....TK..QHKFEDL.TPGKKYKIQIL.TVSGG.....LFS
PTPRB_HUMAN/555-632               AQV.TDLHVANQ..GMTSSLFTNWTQA.....QGDVEFYQVLL...IHENVV............IKNES...ISSE....TS..RYSFHSL.KSGSLYSVVVT.TVSGG.....ISS
PTPRB_HUMAN/1086-1162             AAV.TDLRITEN...STRHLSFRWTAS.....EGELSWYNIFL...YNPDGNL..........QERAQV...DPLV....Q...SFSFQNL.LQGRMYKMVIV.THSGE......LS
PTPRB_HUMAN/1174-1250             ASV.SHLRGSNR..NTTDSLWFNWSPA.....SGDFDFYELIL...YNPNGTK..........KENWKD...KDLT....E....WRFQGL.VPGRKYVLWVV.THSGD......LS
PTPRB_HUMAN/1262-1344             SPP.SLMSFADI...ANTSLAITWKGPP...DWTDYNDFELQW...LPRDALT..........VFNPYN...NRKS....E...GRIVYGL.RPGRSYQFNVK.TVSGDS..WKTYS
PTP10_DROME/865-939               EPI.TQLHATNI...TDTEISLRWDLP.....KGEYNDFDIAY...LTADNL............LAQNM...TTRN....E....ITISDL.RPHRNYTFTVV.VRSGT.....ESS
PTP10_DROME/584-661               NPP.RNMTIETV...RSNSVLVHWSPPE....SGEFTEYSIRY...RTDSEQQ...........WVRLP...SVRS....T...EADITDM.TKGEKYTIQVN.TVSFG.....VES
NGCA_CHICK/702-794                RNP.GGVHGEGN...ETGNLVITWEPLPPQAWNAPWARYRVQW..R.PLEEPGGGGP..SGGFPWAEST...VDAP....P....VVVGGL.PPFSPFQIRVQ.AVNGAG..KGPEA
CNTN2_CHICK/604-692               GPP.GGVVVRDI...GDTTVQLSWSRGF..DNHSPIARYSIEA..R.TLLSNKWK......QMRTNPVN...IEGN....AE..TAQVVNL.IPWMDYEFRVL.ASNILG..VGEPS
MYPC2_CHICK/632-717               DPP.QSVRVTSV...GEDWAVLSWEAPP.FDGGMPITGYLMER...KKKGSMR.........WMKLNFE...VFPD....T...TYESTKM.IEGVFYEMRVF.AVNAIG..VSQPS
MPSF_CHICK/700-785                SYP.HGITLLNC...DGHSMTLGWKAPK.YSGGSPILGYYIDK..R.EANHKN...........WHEVNSSVISRT....I....YTVEDL.TEDAFYEFKIA.AANVVG..IGHPS
MPSF_CHICK/802-887                GPA.YDLTVCEV...RNTSLVLLWKAPV.YEGKSPITGYLVDY...KEVDTED...........WITAN...EKPT....SH.RYFKVTDL.HQGHTYVFKVR.AVNDAG..VGKSS
MPSF_CHICK/372-457                GAP.MDVKCHDA...NRDYVIVTWKPPN.TTSQNPVIGYFVDK...CEVGLEN...........WVQCN...DAPV....KI.CKYPVTGL.YEGRSYIFRVR.AVNSAG..ISRPS
MPSF_CHICK/500-585                GPP.TNVHASEI...SKTYVVLSWDPPV..PRGREPLTYFIEK...SMVGSGS...........WQRVNAQVAVKS....P...RYAVFDL.AEGKPYVFRVL.SANKHG..ISDPS
MYPC2_CHICK/925-1006              GPP.QAVRVMEV...WGSNALLQWEPPK.DDGNAEISGYTVQK...ADTRTME...........WFTVL...EHSR....PT..RCTVSEL.VMGNEYRFRVY.SENVC.....GTS
F4H3U7_CELFA/652-733              TTP.GTPVATGV...TTVGASLSWAAST..DAGSGVAGYEL.Y..R.VQGTTQ...........TLVGT...TTAA....A....YILRDL.TPGTAYSYVVK.AKDVAG.NVSAAS
MYLK_CHICK/1319-1403              DPPAGTPCASDI...RSSSLTLSWYGSS.YDGGSAVQSYTVEI...WNSVDNK...........WTDLT...TCRS....T...SFNVQDL.QADREYKFRVR.AANVYG..ISEPS
MPSF_CHICK/601-684                SAP.GRVVATRN...TKTSVVVQWDKPK...HEENLYGYYIDY...SVVGSNQW........EPANHKP...INYN....R....FVVHGL.ETGEQYIFRVK.AVNAVG..FSENS
NRCAM_CHICK/624-709               NPP.LDLELTGQ...LERSIELSWVPGE..ENNSPITNFVIEY...EDGLHEP.........GVWHYQT...EVPG....SH..TTVQLKL.SPYVNYSFRVI.AVNEIG..RSQPS
LAR_DROME/323-404                 TAP.TDVQISEV...TATSVRLEWSYK....GPEDLQYYVIQY...KPKNANQ...........AFSEI...SGII....TM..YYVVRAL.SPYTEYEFYVI.AVNNIG..RGPPS
NCAM1_BOVIN/611-691               SAP.KLEGQMGE...DGNSIKVKLIKQD..DGGSPIRHYLVKY..R.ALSSEW...........KPEIR...LPSG....SD..HVMLKSL.DWNAEYEVYVV.AENQQ.....GKS
NCAM1_BOVIN/510-597               SSP.SIDQVEP....YSSTAQVQFDEPE.ATGGVPILKYKAEW..R.AMGEEV.........WHSKWYD...AKEA....SMEGIVTIVGL.KPETTYAVRLA.ALNGKG..LGEIS
FINC_BOVIN/610-692                SGP.VQVIITETP.SQPNSHPIQWSAPE....SSHISKYILRW...KPKNSPD..........RWKEAT...IPGH....LN..SYTIKGL.RPGVVYEGQLI.SVQHY....GQRE
PTPRB_HUMAN/24-103                PER.CNFTLAESK.ASSHSVSIQWRIL......GSPCNFSLIY...SSDTLGA.........ALCPTFR...IDNT....TY..GCNLQDL.QAGTIYNFRII.SLDEE......RT
TIE2_HUMAN/640-724                PQP.ENIKISNI...THSSAVISWTILD....GYSISSITIRY...KVQGKNE.........DQHVDVK...IKNA....TI.TQYQLKGL.EPETAYQVDIF.AENNIG..SSNPA
PTP69_DROME/237-321               PQV.SIDFAKAV...GANKIYLNWTVND...GNDPIQKFFITL...QEAGTPTF........TYHKDFI...NGSH....T...SYILDHF.KPNTTYFLRIV.GKNSIG..NGQPT
TENA_CHICK/1228-1306              PEV.DNLLVSDA...TPDGFRLSWTAD.....DGVFDSFVLKI..RDTKRKSD...........PLELI...VPGH....ER..THDITGL.KEGTEYEIELY.GVSSG.....RRS
TENA_CHICK/1046-1124              PEL.GNLSVSET...GWDGFQLTWTAA.....DGAYENFVIQV...QQSDNPE..........ETWNIT...VPGG....QH..SVNVTGL.KANTPYNVTLY.GVIRG.....YRT
TENA_HUMAN/1257-1335              PDM.GNLTVTEV...SWDALRLNWTTP.....DGTYDQFTIQV...QEADQVE..........EAHNLT...VPGS....LR..SMEIPGL.RAGTPYTVTLH.GEVRG.....HST
TENA_CHICK/1137-1215              PEV.GELTVSDI...TPESFNLSWTTT.....NGDFDAFTIEI...IDSNRLL..........EPMEFN...ISGN....SR..TAHISGL.SPSTDFIVYLY.GISHG.....FRT
TENA_HUMAN/1530-1608              PLL.ENLTISDI...NPYGFTVSWMAS.....ENAFDSFLVTV...VDSGKLL..........DPQEFT...LSGT....QR..KLELRGL.ITGIGYEVMVS.GFTQG.....HQT
EPHB2_CHICK/327-422               SAP.QAV.ISSV...NETSLMLEWTPPR.DSGGREDLVYNIIC...KSCGSGRGAC....TRCGDNVQF...APRQLGLTEP..RIYISDL.LAHTQYTFEIQ.AVNGVT.DQSPFS
EPHA3_CHICK/326-421               SAP.RNV.ISNI...NETSVILDWSWPL.DTGGRKDVTFNIIC...KKCGGSSKIC....EPCSDNVRF...LPRQT.GLTN.TTVTVVDL.LAHTNYTFEID.AVNGVS.DLSTLS
EPHA1_HUMAN/334-431               SAP.RNLSFSA....SGTQLSLRWEPPA.DTGGRQDVRYSVRC...SQCQGTAQDGGPCQPCGVGVHFSPGARGLT....TP..AVHVNGL.EPYANYTFNVE.AQNGVS..GLGSS
EPHA2_HUMAN/330-419               SAP.HYLTAVGM...GA.KVELRWTPPQ.DSGGREDIVYSVTC...EQCWPESGEC...GPCEASVRYS...EPPHG.LTRT..SVTVSDL.EPHMNYTFTVE.ARNGV.......S
#=GR EPHA2_HUMAN/330-419    SS    --B.S-EEEE--...TT.SEEEEE--BS.S--S-S--EEEEEE...EEE-S-SS-E...EE--TTSEES...S-SSS.BSSS..EEEEES-.-ST-EEEEEEE.EE-TT.......G
7LESS_DROVI/1918-1997             YAPLPPLQLIEL...NAYGMTLAWPGT.....PDALSSLTLEC...QSLREQ.............LQFN...VAGN....HT..QMRLAPL.QPKTRYSCRLA.LAYAAT..PGAPI
TIE2_HUMAN/544-626                PPP.RGLNLLPK...SQTTLNLTWQPIF..PSSEDDFYVEVER...RSVQKSD...........QQNIK...VPGN....LT..SVLLNNL.HPREQYVVRAR..VNTKA..QGEWS
KALM_CHICK/178-269                LKPRKELKFIEL...QSGDLEVKWSSKF..NISIEPVIYVVQR..RWNQ.GIHPS.....EDDATNWQT...VAQT....TD.ERVQLSDI.RASRWYQFRVA.AVNVHG..TRGFT
LAR_DROME/516-598                 SQP.SNFRATDI...GETAVTLQWTKPT..HSSENIVHYELYW...NDTYANQ...........AHHKR...ISNS....E...AYTLDGL.YPDTLYYIWLA.ARSQRG..EGATT
PTPRZ_HUMAN/313-401               SEP.ENVQADPE...NYTSLLVTWERPR.VVYDTMIEKFAVLY...QQLDGED.........QTKHEFL...TDGY....QD.LGAILNNL.LPNMSYVLQIV.AICTNG.LYGKYS
EPHA2_HUMAN/437-519               TEP.PKVRLEGR...STTSLSVSWSIPP..PQQSRVWKYEVTY...RKKGDS.............NSYN...VRRT....EG.FSVTLDDL.APDTTYLVQVQ.ALTQEG..QGAGS
#=GR EPHA2_HUMAN/437-519    SS    ---.-EEEEEEE...-SS-EEEEEE--C..CCTTT-SEEEEEE...EESS--.............S-EE...EEEE....SS.SEEEE-S-.-SS-EEEEEEE.EESSSS..--EE-
TIE1_HUMAN/645-729                PAP.RHLHAQAL...SDSEIQLTWKHPE..ALPGPISKYVVEV...QVAGGAG..........DPLWID...VDRP....EE.TSTIIRGL.NASTRYLFRMR.ASI.QG..LGDWS
ITB4_HUMAN/1529-1612              DTP.TRLVFSAL...GPTSLRVSWQEPR...CERPLQGYSVEY...QLLNGGE...........LHRLN...IPNP....AQ.TSVVVEDL.LPNHSYVFRVR.AQSQEG..WGRER
#=GR ITB4_HUMAN/1529-1612   SS    ---.---EEEEE...CTTEEEEE-----...-SS-EEEEEEEE...EETTS--...........EEEEE...ES-T....T-.-EEEEES-.-TT-EEEEEEE.EEETTE..EEEEE
ITB4_HUMAN/1221-1310              SEP.GRLAFNVV...SSTVTQLSWAEPA..ETNGEITAYEVCY...GLVNDDNRP......IGPMKKVL...VDNP....KN.RMLLIENL.RESQPYRYTVK.ARNGAG..WGPER
#=GR ITB4_HUMAN/1221-1310   SS    ---.S--EEEEE...SSSEEEEE----S..S-SS-EEEEEEEE...EEB-TTS-B......SS--EEEE...ESST....TS.SEEEEES-.-TT-EEEEEEE.EEETTE..E--BE
ITB4_HUMAN/1642-1728              SAP.GPLVFTAL...SPDSLQLSWERPR..RPNGDIVGYLVTC...EMAQGGG..........PATAFR...VDGDS..PES..RLTVPGL.SENVPYKFKVQ.ARTTEG..FGPER
#=GR ITB4_HUMAN/1642-1728   SS    TS-.---EEEEE...ETTEEEEEEE--S..S-SS-EEEEEEEE...EETTSSS..........--EEEE...EES--..SEE..EEEE-S-.-TT--EEEEEE.EEESS-..EEEEE
PTP10_DROME/959-1044              GRV.ERFHPTDV...QPSEINFEWSLPS.SEANGVIRQFSIAY...TNINNLT...........DAGMQ...DFES....EE.AFGVIKNL.KPGETYVFKIQ.AKTAIG..FGPER
EPHB2_CHICK/438-521               SAV.SIMHQVSR...TVDSITLSWSQPD..QPNGVILDYELQY...YEKNLSE...........LNSTA...VKSP....TN..TVTVQNL.KAGTIYVFQVR.ARTVAG..YGRYS
EPHA4_MOUSE/442-525               SSI.ALVQAKEV...TRYSVALAWLEPD..RPNGVILEYEVKY...YEKDQNE............RSYR...IVRT....AA.RNTDIKGL.NPLTSYVFHVR.ARTAAG..YGDFS
LAR_DROME/911-995                 GPP.SNITIRFQ...TPDVLCVTWDPPTREHRNGIITRYDVQF..HKKIDHGL...........GSERN...MTLR....K....AVFTNL.EENTEYIFRVR.AYTKQG..AGPFS
NRCAM_CHICK/929-1014              SPP.SFLKITNP...TLDSLTLEWGSPT..HPNGVLTSYILKF...QPINNTHE.......LGPLVEIR...IPAN....ES..SLILKNL.NYSTRYKFYFN.AQTSV....GSGS
7LESS_DROME/1800-1891             SPP.RNFSVRVL...SPRELEVSWLPPE..QLRSESVYYTLHW...QQELDGENVQ...DRREWEAHER...RLET....AG..THRLTGI.KPGSGYSLWVQ.AHATPT..KSNSS
E1JJF8_DROME/918-1007             SPV.QGLDAYPL...GSSAFMLHWKKPL..YPNGKLTGYKIYY...EEV.KESYVG...ERREYDPHIT...DPRV....T...RMKMAGL.KPNSKYRISIT.ATTKMG..EGSEH
ITB4_HUMAN/1128-1208              GAP.QNPNAKAA...GSRKIHFNWLPP.....SGKPMGYRVKY...WIQGDSE..........SEAHLL...DSKV....P...SVELTNL.YPYCDYEMKVC.AYGAQG..EGPYS
#=GR ITB4_HUMAN/1128-1208   SS    ---.EEEEEEE-...SSS-EEEEEE--.....SS-ESEEEEEE...EETTS-T..........TS-EEE...EESS....S...EEEE-S-.-TT-EEEEEEE.EEETTE..EEEE-
UFO_HUMAN/335-418                 GPP.ENISATR....NGSQAFVHWQEPR.APLQGTLLGYRLAY...QGQDTPE...........VLMDI...GLRQ....EV..TLELQGD.GSVSNLTVCVA.AYTAAG..DGPWS
E1JJF8_DROME/817-905              DAP.TNFTMRQI..TSSTSGYMAWTPVSEESVRGHFKGYKIQT...WTENEGE.........EGLREIH...VKGD....TH..NALVTQF.KPDSKNYARIL.AYNGRF..NGPPS
CNTN2_CHICK/809-896               VAP.FRVTAKAV...LSSEMDVSWEPVEQGDMTGVLLGYEIRY...WKDGDKEE........AADRVRT...AGLV....T...SAHVTGL.NPNTKYHVSVR.AYNRAG..AGPPS
CNTN1_CHICK/801-884               EVP.TDVSVKVL...SSSEISVSWHHVT....EKSVEGYQIRY...WAAHDKE.........AAAQRVQ...VSNQ....EY..STKLENL.KPNTRYHIDVS.AFNSAG..YGPPS
#=GR CNTN1_CHICK/801-884    SS    S--.EEEEEEE-...SSS-EEEEEE---....-TT--EEEEEE...EETTS-G.........GG-EEEE...EETT....-S..EEEE-S-.-TT-EEEEEEE.EEETTE..E----
TIE1_HUMAN/547-632                LQP.WLEGWHVE...GTDRLRVSWSLPL.VPGPLVGDGFLLRL...WDGTRGQ...........ERREN...VSSP....QA.RTALLTGL.TPGTHYQLDVQ.LYHCTL..LGPAS
L1CAM_HUMAN/813-907               QAI.PELEGIEI..LNSSAVLVKWRPVDLAQVKGHLRGYNVTY...WREGSQRKHS...KRHIHKDHVV...VPAN....TT..SVILSGL.RPYSSYHLEVQ.AFNGRG..SGPAS
#=GC SS_cons                      TSBSCEEEEEEE..TSSSEEEEEEE-CSGCSSSSTECEEEEEE...EETTSSSSBE...EESCTEEEEE...EESTS.BSCS.SEEEEESS.STTEEEEEEEE.EEETTE.SEEEEE
#=GC seq_cons                     ssP.pslphpsh...ssssltlsWpss.....suslssYplph...tptsssp...........hpphs...lsss....p...phslpsL.pPsspYplpVt.uhsst.....t.S
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